Project Overview

The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Research Engineer/Research Engineer for a project: “The pathobiology of tRNA modifications in cardiac development and diseased cell states”. This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome and proteome in cardiac cell development and disease states, and to characterize potential next-generation early detection biomarkers for heart failure to complement existing clinical biomarkers. The successful candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific and translational research.

Responsibilities

This role will suit an individual passionate about cardio-biology and proteomics studies to understand molecular mechanisms of protein translation and to develop potential biomarkers in heart development and disease. The candidate will be able to:

- Design and perform proteomics experiments (eg, TMT, DIA, DDA)

- Develop and optimize sample preparation workflows

- Perform operation, maintenance and data acquisition on high-resolution mass spectrometers

- Analyze data using advanced pipelines and support biological interpretation.

- characterize and develop potential biomarkers for early detection of heart failure

- Ensure compliance with lab safety, QC standards, and data integrity policies

- Maintains highly organized sample and data tracking and reporting workflow

Requirements

- BS or MS in biochemistry, analytical chemistry, chemical engineering or related field

- Experience in mass spectrometry-based proteomics and data analysis

- Experience in sample preparation for proteomics analysis

- Experience in operating Thermo nano liquid chromatography and Orbitrap mass spectrometer

- Familiar with proteomics software as well as other bioinformatics tools and databases

- Excellent attention to detail, organizational skills, and ability to maintain accurate and detailed records.

- Strong communication and the ability to collaborate effectively with cross-functional teams.

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.