Project Overview

The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Laboratory Technologist / Laboratory Technologist for a project: “The pathobiology of tRNA modifications in cardiac development and diseased cell states”. This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome and proteome in cardiac cell development and disease states. The successful candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific research.

Key Responsibilities

This role will suit an individual passionate about cardio-biology and proteomics studies to understand molecular mechanisms of protein translation in heart development and disease. The candidate will be able to:

- Design and perform proteomics experiments (eg, TMT, DIA, DDA)

- Develop and optimize sample preparation workflows

- Perform operation, maintenance and data acquisition on high-resolution mass spectrometers

- Analyze data using advanced pipelines and support biological interpretation.

- Ensure compliance with lab safety, QC standards, and data integrity policies

- Maintains highly organized sample and data tracking and reporting workflow

Requirements

- BS or MS in biochemistry, analytical chemistry or related field

- Experience in mass spectrometry-based proteomics and data analysis

- Experience in sample preparation for proteomics analysis

- Experience in operating Thermo nano liquid chromatography and Orbitrap mass spectrometer

- Familiar with proteomics software as well as other bioinformatics tools and databases

- Excellent attention to detail, organizational skills, and ability to maintain accurate and detailed records.

- Strong communication and the ability to collaborate effectively with cross-functional teams.

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.