Project Overview

The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Postdoctoral Associate/Postdoctoral Associate for a project: “The pathobiology of tRNA modifications in cardiac development and diseased cell states”. This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome in cardiac cell development and disease states. The successful candidate will primarily be responsible for leading the project involving RNA epitranscriptomics, nucleic acid, protein sample preparation and molecular/biochemistry work from a variety of cardiac cell and clinical models. The candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific research.

Key Responsibilities

This role will suit an individual passionate about cardio-biology and omics studies to understand molecular mechanisms of protein translation in heart development and disease. The candidate will be able to:

- Lead and optimize protocols for mass spectrometry (epitranscriptomics and proteomics), next-gen sequencing (absolute quantification), RNA modification pathway analysis, and various biological processes (i.e. iPSC differentiation)

- Design experiments to differentiate hiPSCs into cardiac and other cell lineages following established protocols or adapt protocols to answer relevant biological questions that will arise.

- Collaborate with cross-functional, cross-cultural teammates, the NUS academic/clinical communities, and the wider scientific community.

- Communicate scientific discoveries through publications, presentations at local and international conferences, and as required in technology disclosure and intellectual property filing.

Requirements

- Ph.D. in a relevant scientific field (e.g., stem cell biology, biotechnology, cell biological engineering or a related discipline) with a good track record of publication and productivity.

- Strong background and hands-on experience in multi-omics platforms, next-gen sequencing, and corresponding data analysis is required.

- Expertise in molecular biology techniques, hiPSC culture, differentiation, characterization techniques is highly desirable.

- Excellent attention to detail, organizational skills, and ability to maintain accurate and detailed records.

- Strong communication and the ability to collaborate effectively with cross-functional teams.

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.